The leave side won just after 6am, as it became clear that nothing could swing the vote back in favor of the Remain campaign.
As a result of the vote global markets plunged on Friday. The British pound fell to a three-decade low as more counting areas reported their results.
The vote had a turnout of 72 percent of the more than 46 million registered voters.
Vote to leave the European Union could destabilize 28-nation trading bloc, created from ashes of WW II.